TABLE 1

Metabolic characteristics of genotypic groups for SNP rs3738435 among 282 NGT full-heritage Pima Indians studied for early insulin secretion

Genotype
P value
C/CC/TT/TAdditiveDominantRecessive
n9114249
Age (years)27 ± 126 ± 126 ± 1
Percent body fat32 ± 131 ± 132 ± 1
    Adjusted*32 ± 132 ± 131 ± 10.510.760.47
Fasting plasma glucose (mg/dl)90 ± 187 ± 187 ± 1
    Adjusted*§89 ± 187 ± 187 ± 10.020.400.008
OGTT 30 min glucose (mg/dl)145 ± 3141 ± 2136 ± 3
    Adjusted*§145 ± 3141 ± 2136 ± 30.050.080.11
OGTT 60 min glucose (mg/dl)142 ± 4140 ± 3126 ± 4
    Adjusted*§140 ± 4141 ± 3124 ± 40.030.0010.45
OGTT 120 min glucose (mg/dl)107 ± 2110 ± 2106 ± 3
    Adjusted*§106 ± 2110 ± 2105 ± 30.920.200.34
Log10 fasting insulin (μU/ml)1.52 ± 0.021.52 ± 0.021.51 ± 0.03
    Adjusted*§1.52 ± 0.011.53 ± 0.011.50 ± 0.020.780.320.62
OGTT log10 30 min insulin (μU/ml)2.39 ± 0.032.31 ± 0.022.37 ± 0.04
    Adjusted*§2.38 ± 0.022.30 ± 0.022.40 ± 0.030.880.030.06
OGTT log10 120 min insulin (μU/ml)2.09 ± 0.032.07 ± 0.032.02 ± 0.05
    Adjusted*§2.08 ± 0.032.09 ± 0.022.01 ± 0.050.280.140.75
    Adjusted*§2.07 ± 0.032.08 ± 0.022.05 ± 0.040.830.510.81
Log10 glucose disposal rate (mg · kg EMBS−1 · min−1)0.56 ± 0.010.57 ± 0.010.60 ± 0.02
    Adjusted*§0.56 ± 0.010.57 ± 0.010.60 ± 0.020.020.050.10
Log10 AIR (μU/ml) (IVGTT)2.33 ± 0.032.34 ± 0.022.44 ± 0.03
    Adjusted*§2.33 ± 0.032.33 ± 0.022.46 ± 0.030.020.000060.35
  • Data are raw means ± SE and adjusted means ± SE for each trait grouped by genotype. P values were calculated for the adjusted means. Significant P values (<0.05) are shown in bold. Covariates for adjustments are listed as:

  • *

    * age,

  • sex,

  • family membership,

  • §

    § percentage of body fat,

  • glucose disposal rate, and

  • 30-min glucose levels. IVGTT, intravenous glucose tolerance test. EMBS, estimated metabolic body size.