TABLE 2

Association of rs3738435 with early-onset type 2 diabetes in Pima Indians

Genotype vs. diabetes status
AdditiveDominantRecessive
C/CC/TT/TTotal
Early-onset type 2 diabetes
    n (%)88 (25)196 (56)64 (18)348
    P value0.480.020.2
    Odds ratio (95% CI)1.07 (0.88–1.3)1.44 (1.05–1.98)0.82 (0.61–1.1)
Nondiabetic subjects
    n (%)105 (27)188 (48)99 (25)392
  • Data are n (%) unless otherwise indicated. P values were adjusted for sex, Pima heritage, and sibship. Early onset defined as age of onset <25 years. Significant P values (<0.05) are shown in bold.