TABLE 3

Clinical characteristics by ethnicity and SNP rs12255372 genotype

Clinical characteristicsEuropean Americans
African Americans
GGGTTTGGGTTT
n685713604711
Age (years)33 ± 1236 ± 1336 ± 1328 ± 1234 ± 12*33 ± 10*
IFG [n (%)]4 (5)8 (14)1 (7)3 (5)7 (14)1 (9)
BMI (kg/m2)26.6 ± 3.826.5 ± 4.228.6 ± 7.427.1 ± 4.327.9 ± 3.827.6 ± 3.5
Percent fat mass39.6 ± 7.238.3 ± 7.540.7 ± 7.436.4 ± 7.738.5 ± 8.035.9 ± 5.6
Fasting glucose (mg/dl)90.4 ± 7.391.0 ± 7.091.3 ± 8.888.7 ± 6.288.5 ± 8.188.7 ± 6.0
Fasting insulin (μU/ml)10.4 ± 1.310.6 ± 1.510.5 ± 1.511.5 ± 1.411.8 ± 1.512.1 ± 1.5
Si × 10−4 (min · μU−1 · ml−1)3.52 (3.09–4.08)4.05 (3.43–4.80)3.17 (2.19–4.47)2.59 (2.22–3.01)2.25 (1.91–2.68)2.00 (1.34–2.86)
AIRg (μU · ml−1 · min−1)428 (364–505)428 (358–513)317 (223–451)943 (801–1,126)915 (775–1,090)828 (595–1,153)
DI (Si × AIRg)1,465 (1,239–1,763)1,652 (1,384–2,008)962 (714–1,315)*2,344 (1,983–2,798)1,978 (1,695–2,338)1,587 (1,074–2,356)*
  • Data are n (%), means ± SE, or geometric means (95% CI).

  • *

    * P < 0.05 for the comparison with major allele. n (%) refers to the number and percentage of subjects with IFG.