Baseline characteristics of the examined probands and patients
| Proband | Sex | HLA alleles | Autoantibodies | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DRB1* | DQB1* | GADA | IA-2A | IAA | ICA | ||||||
| T1D-1 | F | 0401,0801 | 0301,0302 | + | + | − | + | ||||
| T1D-2 | M | ND | ND | + | + | ND | + | ||||
| T1D-3 | F | 1101,15 | 0301,0602 | − | − | − | − | ||||
| T1D-4 | M | 0301,06 | 0201/− | + | + | ND | − | ||||
| T1D-5 | F | 0401,06 | 0302/− | ND | ND | ND | ND | ||||
| T1D-6 | F | 0405,06 | 0302/− | + | + | ND | + | ||||
| T1D-7 | M | 0401,0401 | 0301,0302 | + | + | + | + | ||||
| T1D-8 | F | 0701,0801 | ND | ND | ND | ND | ND | ||||
| T1D-9 | M | 0401,1301 | ND | ND | ND | ND | ND | ||||
| T1D-10 | M | 0401,0402 | 0302,0302 | + | + | − | − | ||||
| T1D-11 | M | ND | ND | + | + | + | − | ||||
| T1D-12 | M | 0404,1001 | 0302,0501 | + | − | + | − | ||||
| T1D-13 | F | 0401,0401 | 0301,0302 | ND | ND | ND | ND | ||||
| T1D-14 | F | 0801,1601 | 0302,0502 | ND | ND | ND | ND | ||||
| T1D-15 | M | 0301,0401 | 0201,0302 | − | − | − | − | ||||
| T1D-16 | F | 0401,0401 | 0302,0302 | ND | ND | ND | ND | ||||
| T1D-17 | F | 0301,0401 | 0201,0302 | + | + | + | + | ||||
| T1D-18 | M | 0301,0401 | 0201,0302 | + | − | − | + | ||||
| T1D-19 | M | 0301,0401 | 0201,0302 | + | − | + | − | ||||
| T1D-20 | M | 0401,0401 | 0302,0301 | + | + | + | + | ||||
| T1D-21 | F | 0301,0401 | 0201,0302 | + | + | − | + | ||||
| T1D-22 | M | 0301,0301 | 0201,0201 | + | − | − | + | ||||
| T1D-23 | M | 0401,0401 | 0302,0302 | + | + | + | − | ||||
| T1D-24 | F | ND | ND | − | − | − | − | ||||
| T1D-25 | F | 0401,0701 | 02,0302 | + | − | + | − | ||||
| T1D-26 | M | 0401,0402 | 0302,0302 | + | + | − | − | ||||
| T1D-27 | M | ND | ND | + | + | + | − | ||||
| T1D-28 | M | 0401,0404 | 0302,0302 | + | − | + | − | ||||
| T1D-29 | F | ND | ND | + | − | + | − | ||||
| T1D-30 | M | ND | ND | + | − | + | − | ||||
| T1D-31 | F | 0301,0401 | ND | − | − | − | − | ||||
| T1D-32 | F | 0301,0401 | 0201,0302 | + | − | − | − | ||||
| Pre–T1D-1 | M | 0401,1501 | 0302,0602 | + | − | ND | + | ||||
| Pre–T1D-2 | M | 0301,1601 | 0201,0502 | + | − | ND | + | ||||
| Pre–T1D-3 | M | 0402,1301 | 0302,0603 | + | + | + | + | ||||
| Pre–T1D-4 | M | 0401,0401 | 0302,0302 | + | + | + | + | ||||
| Pre–T1D-5 | F | 0301,1601 | ND | − | − | + | − | ||||
| CP-1 | M | 0404,1001 | 0302,0501 | − | − | − | − | ||||
| CP-2 | M | 0301,0401 | 0201,0302 | − | − | − | − | ||||
| CP-3 | M | 0401,0401 | 0301,0302 | ND | ND | ND | ND | ||||
| CP-4 | F | 0301,0401 | 0501,0301 | ND | ND | ND | ND | ||||
| CP-5 | F | 0401,1601 | 0302,0502 | − | − | − | − | ||||
| CP-6 | F | 0401,1301 | 0302,0603 | ND | ND | ND | ND | ||||
| CP-7 | F | 0401,1501 | 0302,0602 | − | − | − | − | ||||
| CP-8 | F | 0301,13 | 0201,0603 | ND | ND | ND | ND | ||||
| CP-9 | M | 0301,11 | 0201/− | ND | ND | ND | ND | ||||
| CP-10 | F | 0301,0401 | 0201,0302 | − | − | − | − | ||||
| CP-11 | F | 0301,0408 | 0201,0301 | ND | ND | ND | ND | ||||
| CP-12 | F | 0408,0701 | 0302,0303 | − | − | − | − | ||||
| CP-13 | F | 0401,1601 | 0502,0302 | ND | ND | ND | ND | ||||
| CP-14 | M | 1501,04 | 0302,0602 | − | − | − | − | ||||
| CP-15 | M | 0401,1001 | ND | − | − | − | − | ||||
| CP-16 | F | 0401,1501 | 0301,0602 | ND | ND | ND | ND | ||||
| CP-17 | F | 1501,04 | 0302,0602 | − | − | − | − | ||||
| CP-18 | F | 0301,0701 | 0201,0201 | − | − | − | − | ||||
| CP-19 | F | 0401,1301 | 0302,0603 | − | − | − | − | ||||
| CP-20 | F | 0301,0401 | 0201,0302 | − | − | − | − | ||||
| CP-21 | M | 0401,0301 | 0302,0201 | − | − | − | − | ||||
| T2D-1 | F | 1001,15 | 0501,0602 | − | − | − | − | ||||
| T2D-2 | F | 0801,1301 | 0402,0603 | − | − | + | − | ||||
| T2D-3 | F | 0701,1201 | 0201,0603 | − | − | − | − | ||||
| T2D-4 | M | ND | ND | − | − | − | − | ||||
Normal range of autoantibodies: anti-GAD65 autoantibody (GADA) <3.9 Karlsburg units (KU)/l, anti–IA-2 autoantibody (IA-2A) <1.85 KU/l, anti-insulin autoantibody (IAA) <281.48 μU/l, and anti-ICA <20 JDF units. ND, not determined.