TABLE 1

Effect of combined AS-oligos against expression of ECM components, fibronectin, collegen IV, and laminin in cells grown in high glucose medium compared with cells grown in normal medium or cells transfected with Ran-oligos

ECM geneNormalHigh glucoseHigh glucose + antisenseHigh glucose + random
Fibronectin (n = 4) (%)100 ± 29174 ± 32*60 ± 21167 ± 31
Collagen IV (n = 7) (%)100 ± 15156 ± 23*86 ± 24124 ± 17
Laminin (n = 7) (%)100 ± 16128 ± 18*96 ± 29123 ± 17
  • Date are means ± SD (% of control).

  • *

    * P < 0.05 compared with normal;

  • P < 0.05 compared with high glucose.