TABLE 2

Effect of combined AS-oligos against expression of ECM components, fibronectin, collegen IV, and laminin in retinas of diabetic rats

NormalDiabetesAntisenseRandom
1 month
    Fibronectin100 ± 7124 ± 5494 ± 16109 ± 22
    Collagen IV100 ± 21155 ± 87101 ± 38163 ± 108
    Laminin100 ± 31127 ± 5996 ± 21114 ± 18
2 months
    Fibronectin100 ± 6195 ± 38*147 ± 29201 ± 46
    Collagen IV100 ± 14191 ± 48*146 ± 28202 ± 41
    Laminin100 ± 10183 ± 54*128 ± 47184 ± 31
  • Data are means ± SD (% of control).

  • *

    * P < 0.05 compared with control retinas;

  • P < 0.05 compared with diabetic retinas.