TABLE 1

Female apoE-deficient mice subjected to multiple low-dose intraperitoneal injections of STZ and, as a control, sustained release insulin implants inserted in a subgroup of STZ-injected mice

ControlSTZSTZ + insulin
Tissues
    n13136
    Body mass (g)19.4 ± 0.917.6 ± 1.5*17.4 ± 2.1*
    Liver mass (g)0.83 ± 0.110.96 ± 0.11*0.84 ± 0.16
    Fat pad mass (g)0.16 ± 0.010.068 ± 0.022*ND
Plasma
    n181810
    Glucose (mmol/l)10.3 ± 2.618.5 ± 2.6*16.7 ± 5.6
    Triglycerides (mmol/l)0.92 ± 0.311.00 ± 0.181.45 ± 0.80
    Cholesterol (mmol/l)
        15-week-old mice9.4 ± 1.112.0 ± 6.413.8 ± 7.0
        20-week-old mice19.4 ± 2.330.4 ± 1.8*ND
Lesion
    n181810
    Lesion area (104 μm2)5.4 ± 2.210.0 ± 3.43.9 ± 0.8
  • Data are means ± SE unless otherwise indicated.

  • *

    * P < 0.01 relative to corresponding control;

  • not significant;

  • P < 0.05 relative to corresponding control. ND, no data.