TABLE 4

Insulin clamp characteristics in C57BL/6J mice by time fasted and amount of insulin priming dose

5-h fast
18-h fast
16 mU/kg300 mU/kg16 mU/kg300 mU/kg
n61077
Glucose (mg/dl)125 ± 1*132 ± 3129 ± 6124 ± 5
GIR (mg · kg−1 · min−1)41 ± 236 ± 257 ± 758 ± 6
Insulin (μU/ml)36 ± 3*51 ± 337 ± 337 ± 6
EndoRa (mg · kg−1 · min−1)−4 ± 1*9 ± 1−5 ± 30 ± 3
Rd (mg · kg−1 · min−1)38 ± 2*45 ± 250 ± 556 ± 6
Glycolytic rate (mg · kg−1 · min−1)18 ± 116 ± 123 ± 325 ± 3
  • Data are means ± SE and represent the average of five measurements during the last 40 min of the clamp period.

  • *

    * P < 0.05 vs. 5-h fast, 300 mU/kg;

  • P < 0.05 vs. 18-h fast, 16 mU/kg;

  • P < 0.05 vs. 18-h fast, 300 mU/kg.