TABLE 5

Insulin clamp characteristics in C57BL/6J mice by insulin dose

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Glucose (mg/dl)150 ± 5*135 ± 4125 ± 1138 ± 4133 ± 4
GIR (mg · kg−1 · min−1)2 ± 241 ± 2§49 ± 573 ± 3
Insulin (μU/ml)14 ± 212 ± 137 ± 3§72 ± 3183 ± 14
EndoRa (mg · kg−1 · min−1)15 ± 118 ± 1−4 ± 11 ± 32 ± 3
Rd (mg · kg−1 ·· min−1)13 ± 2*20 ± 238 ± 2§47 ± 574 ± 5
  • Data are means ± SE. Insulin dose given as milliunits per kilogram per minute. Data represent the average of five measurements during the last 40 min of the clamp period, except for the insulin dose 0 mU · kg−1 · min−1, which represents pooled averages from basal measurements from all mice.

  • *

    * P < 0.05 vs. 0.8, 2.5, 4, and 20 mU · kg−1 · min−1;

  • P < 0.05 vs. 2.5, 4, and 20 mU · kg−1 · min−1;

  • P < 0.05 vs. 0.8, 4, and 20 mU · kg−1 · min−1;

  • §

    § P < 0.05 vs. 4 and 20 mU · kg−1 · min−1;

  • P < 0.05 vs. 20 mU · kg−1 · min−1.