TABLE 1

Adiponectin SNP genotype and allele frequencies in non-Hispanic whites and African Americans

LocationdbSNP no.Gene regionAlleles (1/2)*Whites
African Americans
Genotype distribution*
Allele 2 frequencyGenotype distribution*
Allele 2 frequency
111222111222
−12,823rs860291PromoterC/T0.780.210.010.110.930.0700.04
−11,391rs17300539PromoterG/A0.840.150.010.080.970.0300.01
−10,068rs182052Intron 1G/A0.480.400.120.320.420.440.140.36
−4,521rs822393Intron 1C/T0.590.350.060.240.460.430.110.32
−4,041rs822395Intron 1A/C0.380.490.130.380.360.390.240.44§
−657rs2036373Intron 1T/G0.870.130.0020.070.880.110.0040.06
+45rs2241766Exon 1T/G0.850.130.020.080.910.09<0.010.05
+276rs1501299Intron 2G/T0.540.390.070.270.420.470.110.35
+349rs2241767Intron 2A/G0.790.190.020.110.910.080.0020.04
+712rs3774261Intron 2G/A0.370.500.130.380.190.500.310.56
+2,019N/A3′ UTRA/Del0.370.500.130.380.210.480.310.55
  • UTR, untranslated region.

  • *

    * 1 and 2 denote alternate alleles; 11 homozygous for allele 1 and 12 heterozygous and 22 homozygous for allele 2.

  • Location relative to the transcription start site.

  • Significantly different allele frequency in whites compared with African Americans (P < 0.001).

  • §

    § P value for HWE <0.001; dropped from further analysis.