TABLE 4

Linear regression models of adiponectin level in non-Hispanic whites and African Americans

Whites
African Americans
βP valueβP value
Intercept10.5 ± 0.5<0.00019.8 ± 0.6<0.0001
Sex*2.3 ± 0.3<0.00011.5 ± 0.3<0.0001
Puberty*−1.4 ± 0.50.005−0.9 ± 0.60.10
Post-puberty*−1.4 ± 0.50.007−0.8 ± 0.50.15
BMI Z score−1.1 ± 0.3<0.0001−0.8 ± 0.30.02
Waist Z score−0.2 ± 0.30.5−0.5 ± 0.30.10
Haplotypes
    A/G1.4 ± 0.40.002
    G/G/G−0.9 ± 0.50.063.4 ± 1.50.02
    A/G/T/G/G5.5 ± 1.70.001
    G/G/G/G/G−5.8 ± 1.90.002
    A/G/T/T/A2.0 ± 1.20.10
    G/A/T/G/A−1.2 ± 0.40.002
Model-adjusted R20.2170.154
Model BIC1,4771,284
  • Data are β estimates ± SE (μg/ml).

  • *

    * Reference categories are boys and prepuberty.

  • Two-SNP haplotypes include −11,391/−10,068; three-SNP haplotypes include +45/+276/+349; five-SNP haplotypes include −11,391/ −10,068/+45/+276/+349. Each haplotype is modeled compared with all other haplotypes of the same type.

  • In African Americans, haplotypes G/G/G and G/G/G/G/G are moderately collinear (variance inflation factor ≈ 5.0).