TABLE 1

Metabolic parameters in aP2-SOCS3 transgenic mice

Chow
High-fat diet
NontransgenicTransgenicNontransgenicTransgenic
Fasting glucose (mg/dl)111.75 ± 7.52106.67 ± 15.10141.00 ± 6.10118.57 ± 8.14*
Fasting insulin (ng/ml)0.26 ± 0.060.20 ± 0.020.49 ± 0.060.29 ± 0.08*
Fed glucose (mg/dl)176.57 ± 9.28159.80 ± 15.09198.85 ± 8.05179.28 ± 5.95
Fed insulin (ng/ml)0.92 ± 0.200.91 ± 0.221.76 ± 0.301.08 ± 0.25*
Leptin (ng/ml)5.05 ± 0.723.62 ± 0.4416.46 ± 1.8210.96 ± 1.68*
TNF-α (pg/ml)39.50 ± 1.1340.00 ± 1.2141.37 ± 1.0844.12 ± 2.68
Adiponectin (μ g/ml)11.91 ± 0.6516.55 ± 0.739.89 ± 0.5116.05 ± 0.72*
Triglyceride (mg/dl)132.60 ± 19.0998.40 ± 32.25202.89 ± 37.83100.25 ± 15.77*
Cholesterol (mg/dl)189.38 ± 5.10182.61 ± 10.03363.67 ± 11.22330.64 ± 10.76
Free fatty acids (mmol/l)0.48 ± 0.050.59 ± 0.020.61 ± 0.060.66 ± 0.05
  • Data are means ± SE (n = 8). All measurements were conducted as described in research design and methods.

  • *

    * P < 0.05 vs. high-fat diet nontransgenic.