TABLE 2

Gene expression in adipose tissue and skeletal muscle of aP2-SOCS3 mice

Chow
High-fat diet
NontransgenicTransgenicNontransgenicTransgenic
White adipose tissue
    FAS6.22 ± 1.306.29 ± 0.9512.05 ± 0.336.72 ± 0.34*
    SREBP1C4.39 ± 0.654.61 ± 0.968.45 ± 0.704.76 ± 0.60*
    PPARγ7.82 ± 1.218.91 ± 1.266.37 ± 0.975.59 ± 1.30
    aP211.37 ± 2.2812.01 ± 0.9010.84 ± 0.5611.24 ± 0.73
    GLUT46.53 ± 1.057.45 ± 1.144.06 ± 0.774.78 ± 0.48
    UCP21.66 ± 0.151.60 ± 0.182.98 ± 0.403.06 ± 0.31
    Adiponectin8.29 ± 1.6314.42 ± 2.154.58 ± 1.149.77 ± 1.36*
    TNF-α7.27 ± 1.506.99 ± 0.7419.30 ± 1.7717.1 ± 2.61
Brown adipose tissue
    UCP11.00 ± 0.061.03 ± 0.101.18 ± 0.091.20 ± 0.26
    UCP20.41 ± 0.070.50 ± 0.080.87 ± 0.120.83 ± 0.15
    UCP31.12 ± 0.051.06 ± 0.091.19 ± 0.091.12 ± 0.05
    PGC1α0.42 ± 0.090.44 ± 0.060.51 ± 0.190.39 ± 0.13
    PPARα1.10 ± 0.101.11 ± 0.091.45 ± 0.131.32 ± 0.08
Skeletal muscle
    ACO1.18 ± 0.061.52 ± 0.031.20 ± 0.091.81 ± 0.07*
    CPT10.66 ± 0.050.96 ± 0.100.68 ± 0.041.04 ± 0.05*
    PPARα0.71 ± 0.061.08 ± 0.140.73 ± 0.041.21 ± 0.11*
    UCP20.59 ± 0.070.58 ± 0.061.06 ± 0.091.13 ± 0.11
    UCP30.74 ± 0.070.91 ± 0.071.02 ± 0.061.38 ± 0.08
  • Data are means ± SE (n = 8). All measurements were conducted as described in research design and methods.

  • *

    * P < 0.05 vs. high-fat diet nontransgenic. ACO, acyl-CoA oxidase; CPT1, carnitine palmitoyl transferase-1; UCP, uncoupling protein.