TABLE 1

Baseline characteristics and rates of change in women who had or developed diabetes and women who remained nondiabetic

VariableDiabetes
P value
Yes (n = 24)*No (n = 47)*
Baseline
    Age (years)33 (6)32 (5)0.81
    BMI (kg/m2)32.0 (5.6)30.4 (4.9)0.23
    Fasting glucose (mg/dl)105 (16)97 (8)0.02
    2-h glucose (mg/dl)185 (55)139 (29)0.0008
    Fasting insulin (μU/ml)24.1 (12.2)18.8 (9.3)0.15
    SI§1.01 (0.74)1.68 (1.09)0.001
    AIRg297 (393)714 (714)<0.0001
    Disposition index (SI × AIRg)288 (289)968 (577)<0.0001
Change during follow-up ([final − initial]/time)
    Duration of follow-up (months)44 (18)47 (14)0.41
    BMI (kg/m2 per year)−0.06 (1.70)0.50 (1.05)††0.15
    Fasting glucose (mg/dl per year)19 (34)††1 (3)**0.01
    2-h glucose (mg/dl per year)28 (49)††4 (12)**0.02
    SI (per year)§−0.04 (0.29)0.04 (0.42)0.42
    AIRg (μU · ml−1 · min−1 per year)−26 (99)−96 (180)‡‡0.04
    Disposition index (per year)−33 (58)**−94 (135)‡‡0.01
  • Data are means ± SD.

  • *

    * At any visit for “yes” and at all visits for “no.”

  • For comparison between groups by two-group t test.

  • During 75-g OGTTs.

  • §

    § Calculated by minimal model analysis of IVGTT insulin and glucose data.

  • Incremental insulin area during first 10 min of IVGTT.

  • A measure of β-cell compensation for insulin resistance.

  • **

    ** P < 0.05,

  • ††

    †† P < 0.01, and

  • ‡‡

    ‡‡ P < 0.001 significant change from baseline to final visit within each group, by paired t test.