TABLE 1

PPARG Pro12Ala genotype frequencies, according to glycemic status after 6 years in subjects who were normoglycemic at baseline: the DESIR study

ProProProAlaAlaAla
Normoglycemic2,622 (79.4)653 (19.8)27 (0.8)
IFG129 (84.9)22 (14.5)1 (0.6)
Type 2 diabetes38 (84.2)6 (15.8)0 (0)
Hyperglycemia (IFG + type 2 diabetes)167 (85.2)28 (14.3)1 (0.5)
OR for hyperglycemia (95% CI)*10.67 (0.44–1.01)0.44 (0.06–3.35)
OR for hyperglycemia (95% CI)* (Ala+ vs. ProPro)10.66 (0.44–0.99)§
  • Data are n (%), unless otherwise indicated.

  • *

    * By multiple logistic regression analyses (adjustment for sex, age, and BMI). Codominant model (number of Ala alleles, 0, 1, 2, considered as a continuous variable): OR for hyperglycemia (95% CI) = 0.67 (0.45–0.99), P = 0.043.

  • P = 0.057;

  • P = 0.428;

  • §

    § P = 0.046.