TABLE 4

Characteristics of subjects normoglycemic at baseline who remained free of hyperglycemia (IFG or type 2 diabetes) at 6 years according to PPARG genotypes

Pro12Ala
C1431T
ProProAla+P geno-typeP interaction genotype timeCCT+P geno-typeP interaction genotype time
n2,6226802,491720
Fasting glucose     (mmol/l)
    Baseline5.15 ± 0.015.13 ± 0.020.5250.2635.15 ± 0.015.13 ± 0.020.7360.658
    6 years5.16 ± 0.015.17 ± 0.035.17 ± 0.015.17 ± 0.02
Fasting insulin     (mU/l)
    Baseline5.30 (5.21–5.40)5.15 (4.98–5.33)0.0010.0075.29 (5.19–5.38)5.22 (5.04–5.40)0.1930.260
    6 years6.00 (5.88–6.12)5.50 (5.28–5.72)5.94 (5.81–6.07)5.70 (5.47–5.93)
HOMA-IR
    Baseline1.21 (1.19–1.23)1.17 (1.13–1.22)0.0010.0181.21 (1.18–1.23)1.20 (1.15–1.24)0.2360.242
    6 years1.38 (1.35–1.41)1.26 (1.21–1.31)1.36 (1.33–1.39)1.31 (1.25–1.36)
  • Data are means ± SE or geometric mean (95% CI). P values are from ANCOVA, adjusted for sex, BMI, and age at inclusion.