The association between combinations of APM1 G-11391A and PPARG Pro12Ala and risk of hyperglycemia at 6 years in subjects normoglycemic at baseline: the DESIR study
| GG/ProPro | GG/Ala+ | A+/Ala+ | A+/ProPro | |
|---|---|---|---|---|
| Normoglycemic | 2,148 (65.3) | 554 (16.9) | 123 (3.7) | 462 (14.1) |
| IFG | 100 (65.8) | 16 (10.5) | 7 (4.6) | 29 (19.1) |
| Type 2 diabetes | 29 (65.9) | 5 (11.3) | 1 (2.3) | 9 (20.5) |
| Hyperglycemia (IFG + type 2 diabetes) | 129 (65.8) | 21 (10.7) | 8 (4.1) | 38 (19.4) |
| OR (95% CI) for hyperglycemia* | 0.78 (0.58–1.03)† | 0.56 (0.38–0.81)‡ | 1.10 (0.61–1.96)§ | 1 |
| OR (95% CI) for hyperglycemia* | 1 | 0.60 (0.38–0.98)‖ | 1.33 (0.62–2.83)¶ | 1.53 (1.03–2.25)# |
Data are n (%), unless otherwise indicated.
* Adjusted for sex, age, and BMI;
† P = 0.082;
‡ P = 0.003;
§ P = 0.760;
‖ P = 0.040;
¶ P = 0.460;
# P = 0.033.