TABLE 6

The association between combinations of APM1 G-11391A and PPARG Pro12Ala and risk of hyperglycemia at 6 years in subjects normoglycemic at baseline: the DESIR study

GG/ProProGG/Ala+A+/Ala+A+/ProPro
Normoglycemic2,148 (65.3)554 (16.9)123 (3.7)462 (14.1)
IFG100 (65.8)16 (10.5)7 (4.6)29 (19.1)
Type 2 diabetes29 (65.9)5 (11.3)1 (2.3)9 (20.5)
Hyperglycemia (IFG + type 2 diabetes)129 (65.8)21 (10.7)8 (4.1)38 (19.4)
OR (95% CI) for hyperglycemia*0.78 (0.58–1.03)0.56 (0.38–0.81)1.10 (0.61–1.96)§1
OR (95% CI) for hyperglycemia*10.60 (0.38–0.98)1.33 (0.62–2.83)1.53 (1.03–2.25)#
  • Data are n (%), unless otherwise indicated.

  • *

    * Adjusted for sex, age, and BMI;

  • P = 0.082;

  • P = 0.003;

  • §

    § P = 0.760;

  • P = 0.040;

  • P = 0.460;

  • #

    # P = 0.033.