TABLE 1

Dose and target of intervention, nutritional intake, and levels of plasma insulin, blood glucose, lactate, and blood pH

Group 1: NI/NGGroup 2: HI/NGGroup 3: NI/HGGroup 4: HI/HG
Intervention
    Insulin dose (units · kg−1 · day−1)1.24.01.24.0
    Target glycemia (mg/dl)80–11080–110250–350250–350
Nutritional intake
    Glucose intake (g/day)*27.4 ± 1.947.2 ± 2.464.3 ± 2.875.9 ± 3.1
    Fat intake (g/day)3.5 ± 0.053.3 ± 0.093.4 ± 0.073.5 ± 0.09
    Amino acid intake (g/day)3.5 ± 0.053.3 ± 0.093.4 ± 0.073.5 ± 0.09
Metabolic control
    Plasma insulin (mU/l)43.3 ± 3.4188 ± 16.747.3 ± 3.5199.8 ± 15.9
    Glycemia (mg/dl)93.0 ± 3.485.2 ± 3.5328 ± 11.3314 ± 10.6
    Lactate (mmol/l)§1.5 ± 0.21.9 ± 0.14.1 ± 0.36.2 ± 0.3
    Blood pH7.413 ± 0.017.430 ± 0.017.385 ± 0.017.350 ± 0.01
  • Data are means ± SE over 7 days.

  • *

    * Significant difference between groups (P < 0.03).

  • P > 0.5 NI/NG vs. NI/HG and HI/NG vs. HI/HG, P < 0.0001 normal insulin vs. high insulin groups.

  • P > 0.3 NI/NG vs. HI/NG and NI/HG vs. HI/HG, P < 0.0001 normoglycemic vs. hyperglycemic groups.

  • §

    § P > 0.7 NI/NG vs. HI/NG, P < 0.003 normoglycemic vs. hyperglycemic groups, P < 0.003 HI/HG vs. all other groups.

  • P < 0.04 HI/HG vs. HI/NG.