TABLE 1

Body weight, eWAT weight, and serum parameters in IL-6−/− IL-1Ra−/− mice at 16 weeks of age

Body weight (g)WAT (g)WAT/body weight (%)Insulin (pg/ml)Leptin (pg/ml)Nonesterified fatty acids (mEq/l)
Wild type27.2 ± 0.20.30 ± 0.011.10 ± 0.031,419 ± 40919 ± 26ND
IL-1Ra−/−24.3 ± 0.3*0.21 ± 0.01*0.87 ± 0.02*972 ± 31636 ± 38ND
IL-6−/−27.9 ± 0.10.34 ± 0.011.22 ± 0.031,631 ± 59859 ± 281.19 ± 0.02
IL-6−/− IL-1Ra−/−24.5 ± 0.2*0.21 ± 0.01*0.85 ± 0.02*931 ± 70533 ± 331.11 ± 0.04
  • Data are means ± SE. Statistical significance was calculated by ANOVA followed by either Scheffe’s test (body weight, WAT, WAT/body weight, insulin, and leptin) or the Student’s t test (nonesterified fatty acid).

  • *

    * P < 0.01;

  • P < 0.05. ND, not determined.