TABLE 1

Twenty-four–hour food intake (g) after i3vt insulin or leptin

SexnVehicle1 mU insulin4 mU insulin
Male1028.8 ± 1.0425.0 ± 1.85*21.0 ± 2.91*
Female1820.4 ± 1.5320.6 ± 0.9820.2 ± 1.10
OVX1220.2 ± 0.5718.4 ± 0.9021.4 ± 0.50
Castrated male1025.4 ± 1.0324.9 ± 1.7323.9 ± 1.98
Intact Male + 17 β-estradiol1024.7 ± 0.9724.2 ± 1.2422.9 ± 0.97
SexnVehicle1.0 μg leptin3.5 μg leptin
Male1030.4 ± 1.2329.5 ± 1.3927.0 ± 0.85
Female1822.2 ± 1.7016.8 ± 1.8415.0 ± 2.70
OVX1220.3 ± 0.5918.4 ± 0.7017.2 ± 1.98
Castrated male1026.7 ± 0.7920.9 ± 1.218.7 ± 1.22
Intact male + 17 β-estradiol1027.1 ± 1.4521.3 ± 0.9817.0 ± 0.83
OVX + PE1023.4 ± 2.1317.4 ± 1.6716.7 ± 1.98
OVX + CE1023.9 ± 1.9817.5 ± 2.0115.9 ± 1.23
  • Data are mean ± SE.

  • *

    * ANOVA revealed that insulin

  • leptin

  • significantly reduced food intake (P < 0.05) compared with vehicle. OVX + CE, ovariectomized females with central 17 β-estradiol; OVX + PE, ovariectomized females with peripheral 17 β-estradiol.