TABLE 3

Genotypic association analysis of PYGM SNPs with DI

SNPAllelesMAF1/11/22/2PEmpiric P
rs483962T/C0.321,423 ± 1,1481,399 ± 1,2861,490 ± 1,6750.9370.897
rs477549A/G0.341,515 ± 1,2321,393 ± 1,2711,261 ± 1,5450.2960.412
rs625172C/T0.471,539 ± 1,1241,362 ± 1,3201,400 ± 1,3290.0110.021
rs565688T/A0.301,453 ± 1,1821,384 ± 1,4201,388 ± 1,1700.0180.068
rs686171C/T0.021,442 ± 1,292885 ± 1,0140.0970.218
rs569602T/C0.061,475 ± 1,297954 ± 870<0.0010.003
rs2073798C/A0.481,498 ± 1,1191,359 ± 1,2611,435 ± 1,3900.0320.041
  • Data are phenotypic mean ± SD. Only nondiabetic subjects were included in this analysis. SNPs are order relative to the gene. Alleles are on the antisense strand. P values determined from a genotypic 2-df test. Empiric P values determined from simulation tests using 10,000 replications. Boldface indicates statistical significance.