TABLE 5

Genotypic association analysis of PC SNPs with AIR

SNPAllelesMAF1/11/22/2P valueEmpiric P
rs746018G/A0.46955 ± 7801,079 ± 9371,169 ± 5650.6470.732
rs4244815C/T0.421,035 ± 816992 ± 831935 ± 7830.5440.463
rs896438G/A0.06997 ± 8091,081 ± 972665 ± 0<0.0010.547
rs7119426T/C0.231,077 ± 883906 ± 713721 ± 501<0.0010.014
rs2167457G/A0.241,104 ± 909894 ± 694698 ± 464<0.0010.004
rs7932018C/T0.16995 ± 819991 ± 8161,037 ± 8660.6020.623
rs3741194A/G0.061,031 ± 846763 ± 5341,024 ± 00.0020.554
rs2077432G/A0.311,032 ± 8561,000 ± 827825 ± 5750.2350.317
rs7926787C/G0.251,053 ± 874971 ± 769701 ± 487<0.0010.011
rs6591223A/G0.391,031 ± 8391,002 ± 802861 ± 7360.3460.305
  • Data are phenotypic mean ± SD. Only nondiabetic subjects were included in this analysis. SNPs are order relative to the gene. Alleles are on the antisense strand. P values determined from a genotypic 2-df test. Empiric P values determined from simulation tests using 10,000 replications. Boldface indicates statistical significance.