TABLE 6

Haplotypic association analysis of PC SNPs (rs6591223, rs7926787, rs2077432, rs7932018, rs2167457, and rs7119426) with AIR

HaplotypeFrequencyDispositionP values for each model
Haplo-genotype mean AIR ± SD
DominantAdditiveRecessive+/+*+/−−/−
TGCGCG0.43Neutral0.2310.1910.428928 ± 7571,010 ± 7841,051 ± 805
CACAGA0.20Lower AIR0.0110.002<0.001721 ± 501888 ± 6591,107 ± 851
TGTGCA0.15Neutral0.3390.2640.3041,181 ± 5421,132 ± 913968 ± 743
TGCGCA0.15Neutral0.1170.1000.4731,032 ± 5741,100 ± 830986 ± 779
TGCACA0.050.0010.0020.467718 ± 3001,390 ± 901970 ± 762
  • *

    * AIR ± SD for individuals whose haplo-genotype has two copies of the haplotype of interest;

  • AIR ± SD for individuals whose haplo-genotype has one copy of the haplotype of interest and any other haplotype;

  • AIR ± SD for individuals whose haplo-genotype has any other haplotype combination. Boldface indicates statistical significance.