TABLE 1

Characteristics of 2,434 participants from the three recruited groups of subjects

Severe obesityCoronary artery diseaseGeneral population
n1,101469864
Females822452
Age
    <30 years1300
    30–40 years2223
    40–50 years302138
    50–60 years275234
    ≥60 years82524
BMI (kg/m2)45.8 ± 7.628.2 ± 5.027.6 ± 4.9
Cardiovascular event1.81002.1
Type 2 diabetes analyzed in 2,434 subjects*20.1 (n=1,101)19.0 (n=469)7.3 (n=864)
Fasting FFAs (mg/dl) analyzed in 1,701 subjects*272 ± 102 (n = 898)301 ± 181 (n = 232)244 ± 128 (n = 571)
Fasting triglycerides (mg/dl) analyzed in 2,193     subjects*178.5 ± 92.5 (n = 912)206.5 ± 133.5 (n = 449)153.1 ± 99.4 (n = 832)
Fasting glucose (mg/dl) analyzed in 2,190     subjects*96.1 ± 22.7 (n = 913)96.3 ± 38.7 (n = 446)88.9 ± 13.8 (n = 831)
  • Data are means ± SD or percent.

  • *

    * n indicates the number of subjects included in the SNP analysis. Inclusion criteria were that age, sex, and phenotype was available, that more than six SNPs were successfully genotyped, and, additionally for FFAs, triglycerides, and glucose, that no antidiabetes medications were taken.

  • Plasma FFAs were only measured in 1,922 out of 2,434 subjects with stored plasma samples available.