TABLE 2

Odds ratio (95% CI) for type 2 diabetes (n = 342 out of 2,434) and average glucose concentrations (n = 2,190 due to restriction to subjects with no diabetes medication) for SNP5 and SNP9

Type 2 diabetes
Fasting glucose concentrations (mg/dl)
SNP5 [OR (95% CI); n of MAC; P]SNP9 [OR (95% CI); n of MAC; P]SNP5 [means* (95% CI) for MAC vs. wild type; P]SNP9 [means* (95% CI) for MAC vs. wild type; P]
Entire group
    Standard data analysis2.65 (1.14–6.14); 27; 0.022.47 (1.21–5.03); 39; 0.01111 (102–120) vs. 91 (90–92); 0.0000018107 (100–114) vs. 91 (90–92); 0.0000031
    Adjusted for subgroup3.14 (1.32–7.46); 27; 0.012.38 (0.97–5.80); 39; 0.06110 (102–119) vs. 91 (90–91); 0.0000008106 (99–113) vs. 91 (90–91); 0.000003
    Test heterogeneity§0.580.820.0010.11
    Pooled estimates3.24 (1.33–7.88); 27; 0.0092.81 (1.35–5.89); 39; 0.006108 (101–116) vs. 91 (90–92); 0.0000008105 (99–111) vs. 91 (90–92); 0.000001
Subgroups
    Female subjects1.95 (0.52–7.27); 132.04 (0.73–5.69); 18122 (111–136) vs. 90 (90–91)112 (103–121) vs. 90 (90–91)
    Male subjects3.33 (1.10–10.1); 143.00 (1.11- 8.15); 21100 (88–113) vs. 92 (91–93)102 (91–113) vs. 92 (91–93)
    Severe obesity1.69 (0.34–8.39); 91.75 (0.55–5.57); 16140 (123–158) vs. 94 (93–95)120 (108–132) vs. 94 (93–95)
    Coronary artery disease4.87 (1.18–20.09); 83.86 (1.00–14.84); 9104 (84–128) vs. 91 (89–94)105 (86–128) vs. 91 (89–94)
    General population3.72 (0.74–18.8); 103.94 (1.02–15.3); 1494 (86–103) vs. 88 (87–89)96 (89–103) vs. 88 (87–89)
  • *

    * The retransformed mean computed on the log-scale.

  • Via the logistic or linear regression model adjusted for age and sex.

  • As in † but additional adjusting for the subgroup.

  • §

    § Tested via including an interaction between the subgroup and the genotype.

  • Computed as the inverse variance weighted mean of the estimates per subgroup, Embedded Image and 95% CI(b) = b±1.96 se(b) with b being the log(OR) or the difference in glucose levels comparing minor allele carriers and wild-type by subgroup, i = 1,2,3, and s the corresponding standard error. MAC, minor allele carrier.