TABLE 1

Basic characteristics of the three groups of rats

ParameterControl rats: vehicle treatedSTZ-induced diabetic rats
Vehicle treatedInsulin treated
n888
Body weight (g)417 ± 7326 ± 11*365 ± 6*
Heart weight (g)1.02 ± 0.020.89 ± 0.02*0.91 ± 0.02*
Heart weight–to–body weight ratio (mg:g)2.45 ± 0.062.76 ± 0.112.50 ± 0.09§
Blood glucose (mg/dl)202 ± 7535 ± 29*207 ± 32
Serum insulin (ng/ml)4.20 ± 0.490.91 ± 0.14*2.52 ± 0.35*
Total cholesterol (mg/dl)53.1 ± 2.857.6 ± 2.660.5 ± 4.9
Triglycerides (mg/dl)103.4 ± 10.547.1 ± 4.0*52.6 ± 6.9*
Free fatty acid (mg/dl)1,297 ± 178625 ± 65*650 ± 101*
  • Data are means ± SE.

  • *

    * P < 0.01 vs. control group;

  • P < 0.01 vs. STZ-vehicle group;

  • P < 0.05 vs. control group;

  • §

    § P < 0.05 vs. STZ-vehicle group.