TABLE 1

Plasma, pancreatic, and intestinal hormone characteristics

HF-CTHF-OFSHF-OFS-ExCT GLP-1R−/−OFS GLP-1R−/−
Fasted
    Glucose (mmol/l)7.02 ± 0.18a5.97 ± 0.24b6.94 ± 0.17a6.52 ± 0.196.97 ± 0.19
    Insulin (pmol/l)73.7 ± 10.4a120.5 ± 13.5b81.5 ± 9.6a200.8 ± 25.1235.7 ± 42.7
Fed
    Glucose (mmol/l)8.21 ± 0.38a6.90 ± 0.29b8.35 ± 0.37a8.69 ± 0.189.43 ± 0.44
    Insulin (pmol/l)566.5 ± 54.7a834.7 ± 114.5b558.2 ± 87.1a309.4 ± 59.4352.1 ± 59.5
Epidydymal fat pads (g/100 g body wt)3.15 ± 0.25a1.95 ± 0.15b2.74 ± 0.21a4.65 ± 0.84.62 ± 0.52
Pancreatic insulin (μg/g)283.2 ± 30.8a358.4 ± 24.9b274.7 ± 10a237.5 ± 18.7202.9 ± 9.6
Colonic proglucagon mRNA (RFU)0.45 ± 0.04a0.66 ± 0.04b0.59 ± 0.02b0.44 ± 0.03a0.54 ± 0.02b
  • Data are mean ± SE. Plasma glucose (mmol/l) and insulin (pmol/l) during the fed and fasted states in wild-type (HF) and GLP-1R −/− knockout mice fed a high-fat diet and supplemented with OFS or OFS-Ex or without supplementation (CT). Epidydimal fat pads weight (g/100 g body wt), pancreatic insulin content (μg/g), and colonic proglucagon mRNA (relative fluorescence units [RFU]) were also quantified in all groups. Data with different superscript letters are significantly different (P < 0.05) according to the post-hoc ANOVA statistical analysis convention.