TABLE 2

Indexes of insulin sensitivity and insulin secretion in the different glucose-intolerant groups

NGTIFGIGTCGINGT vs. IFGNGT vs. IGTNGT vs. CGIIFG vs. IGT
ΔG(AUC) (mg · dl−1 · h−1)*74 ± 3497 ± 36124 ± 31128 ± 350.0008<0.0001<0.0001<0.0001
ΔI(AUC) (μU · ml−1 · h−1)*146 ± 96118 ± 80155 ± 96175 ± 1620.060.070.02
ΔI(AUC)/ΔG(AUC)*2.4 ± 1.91.3 ± 0.91.3 ± 0.91.4 ± 1.30.0008<0.0001<0.0001
I0–30/G0–30 (μU/ml per mg/dl)*1.8 ± 1.40.9 ± 0.51.33 ± 1.00.9 ± 0.7<0.00010.002<0.00010.007
HOMA-IR*2.7 ± 2.24.3 ± 4.93.2 ± 2.14.6 ± 3.30.0040.09<0.00010.03
Matsuda index*4.2 ± 2.93.3 ± 1.93.2 ± 2.22.4 ± 2.50.0008<0.0001<0.0001
ISIest0.13 ± 0.050.11 ± 0.040.11 ± 0.050.10 ± 0.05<0.05<0.05<0.001
OGIS*393 ± 62364 ± 56371 ± 66309 ± 590.010.01<0.0001
Basal EGP (mg · kg−1 · min−1)*1.73 ± 0.41.82 ± 0.341.66 ± 0.181.65 ± 0.21
Basal EGP × FPI*19.4 ± 4.330.2 ± 6.424.1 ± 3.129.1 ± 5.20.020.01
TGD/SSPI × 100*6.6 ± 3.18.0 ± 4.33.8 ± 2.23.4 ± 1.20.030.010.008
(ΔI0–30/ΔG0–30) × Matsuda index*36 ± 2215 ± 918 ± 912 ± 6<0.0001<0.0001<0.00010.04
(ΔI0–30/ΔG0–30) (TGD/SSPI) × 100*9.9 ± 5.37.7 ± 4.43.7 ± 2.64.7 ± 2.20.1<0.00010.00070.006
ΔI(AUC)/ΔG(AUC) × (TGD/SSPI)*0.93 ± 0.70.73 ± 0.50.28 ± 0.20.47 ± 0.20.0040.030.02
  • Data are means ± SD. The Matsuda index of insulin sensitivity was calculated according to (31). The ISIest of insulin sensitivity was calculated according to (33). The OGIS index of insulin sensitivity was calculated according to (34).

  • *

    * P < 0.01;

  • P < 0.0001 by ANOVA, indicating that the means of the four groups are significantly different. ΔG(AUC), incremental AUC of glucose during the OGTT; ΔI(AUC), incremental AUC of insulin during the OGTT; SSPI, steady-state plasma insulin during the last 30 min of the insulin clamp.