TABLE 2

DNA binding activities of NFAT5 to OREs in PBMCs and HMCs under high-glucose conditions

ProbesDiabetic nephropathic subjectsDiabetic control subjectsNormal control subjectsHMCs
n26181310
OREA1.50 ± 0.141.18 ± 0.091.40 ± 0.131.38 + 0.22
OREB2.06 ± 0.27*1.33 ± 0.181.11 ± 0.111.84 + 044
OREC1.94 ± 0.211.39 ± 0.110.95 ± 0.052.38 + 1.15§
  • Data are means of fold increases ± SE under high-glucose conditions (31 mmol/l d-glucose) to normal conditions (the density value was defined as 1) in PBMCs and HMCs.

  • *

    * P = 0.033 and 0.023 vs. diabetic and normal control subjects, respectively.

  • P = 0.035 vs. normal conditions.

  • P = 0.024 and 0.002 vs. diabetic and normal control subjects, respectively.

  • §

    § P = 0.003 vs. normal conditions.