TABLE 3

Fold changes in the protein levels of aldose reductase (AKR1B1) and SDH in PBMCs and HMCs under high-glucose conditions

AKR1B1SDH
Diabetic nephropathic subjects1.34 ± 0.17 (n = 17)*1.33 ± 0.13 (n = 15)*
Diabetic control subjects1.03 ± 0.05 (n = 12)1.14 ± 0.15 (n = 9)
HMCs1.30 + 0.06 (n = 10)1.54 + 0.24 (n = 10)§
  • Data are means of fold increases ± SE under high-glucose conditions (31 mmol/l d-glucose) to normal conditions (the density value was defined as 1) in PBMCs and HMCs.

  • *

    * P = 0.032 and P = 0.029 vs. normal conditions in diabetic nephropathic subjects.

  • P = 0.0001 vs. normal conditions in HMCs.