TABLE 2

Main characteristics of type 2 diabetic patients with macroalbuminuria (case subjects) and microalbuminuria (control subjects) with serum creatinine <1.5 mg/dl included in the substudy

VariableMacroalbuminuria (case subjects)Microalbuminuria (control subjects)
Patients (n)2929
Sex (male/female)27/227/2
Age (years)60.0 ± 8.759.0 ± 8.7
Duration of diabetes (months)178.9 ± 113.5*90.8 ± 80.0
Smoking (no/yes/ex-smokers)14/11/415/10/4
BMI (kg/m2)29.3 ± 4.129.9 ± 4.9
sBP (mmHg)149 ± 18145 ± 15
dBP (mmHg)85 ± 1084 ± 9
MAP (mmHg)106 ± 12104 ± 9
A1C (%)7.73 ± 1.73*6.32 ± 1.31
GDR (mg · kg−1 · min−1)5.16 ± 1.615.52 ± 2.56
Serum creatinine (μmol/l)98 ± 19*82 ± 20
GFR (ml/min per 0.1.73 m2)89.95 ± 25.90100.90 ± 26.24
AER (μg/min)1,027.69 ± 737.79*71.21 ± 48.87
Total cholesterol (mmol/l)5.34 ± 0.755.15 ± 0.75
HDL cholesterol (mmol/l)1.14 ± 0.361.04 ± 0.26
LDL cholesterol (mmol/l)4.22 ± 0.884.12 ± 0.75
Triglycerides (mmol/l)2.63 ± 1.67*1.72 ± 1.11
Diet/sulfonylureas/metformin/insulin0/14/14/132/15/17/9
ACEi/diuretics/α-blockers/CCB18/23/5/710/11/3/8
Statins/fibrates8/62/2
  • Data are frequency or means ± SD. ACEi, ACE inhibitor; CCB, calcium channel blocker; dBP, diastolic blood pressure; MAP, mean arterial pressure; sBP, systolic blood pressure.

  • *

    * P < 0.05 vs. patients with microalbuminuria.

  • Fisher’s exact test: diuretics, P = 0.0029.