TABLE 5

Univariate Cox regression analysis for the factors influencing the risk for type 1 diabetes in offspring of parents with type 1 diabetes according to sex of type 1 diabetic parent

VariableOffspring of male proband
Offspring of female proband
RR (95% CI)P valueRR (95% CI)P value
Male sex of offspring versus female sex*0.96 (0.71–1.30)0.781.55 (0.98–2.43)0.06
    Year of birth*
        <19851.00 (—)1.00 (—)
        1985–891.60 (1.04–1.48)1.84 (1.00–3.41)
        1990–941.71 (1.07–2.75)2.88 (1.47–5.64)
        ≥19953.76 (2.26–6.26)<0.00012.10 (0.84–5.26)0.02
    Birth order*
        First1.00 (—)1.00 (—)
        Second0.91 (0.65–1.29)0.99 (0.59–1.65)
        Third or higher1.19 (0.79–1.79)0.512.06 (1.07–4.09)0.08
    Mother’s age at delivery (years)*
        <251.00 (—)1.00 (—)
        25–291.00 (0.70–1.43)1.14 (0.67–1.94)
        ≥301.36 (0.93–2.00)0.211.90 (1.06–3.42)0.08
    Mother’s age at delivery (continuous)1.02 (0.99–1.05)0.301.06 (1.01–1.11)0.03
    Father’s age at delivery (years)*
        <251.00 (—)1.00 (—)
        25–290.94 (0.64–1.40)1.96 (0.99–3.90)
        ≥301.24 (0.83–1.84)0.292.45 (1.23–4.87)0.04
    Father’s age at delivery (continuous)1.03 (1.00–1.06)0.081.04 (1.00–1.07)0.04
    Parent’s age at onset of diabetes (years)
        0–43.75 (2.15–6.55)1.05 (0.40–2.73)
        5–91.78 (1.13–2.82)1.22 (0.62–2.38)
        10–141.29 (0.85–1.97)1.03 (0.56–1.88)
        15–171.00 (—)<0.00011.00 (—)0.83
  • *

    * Interaction term between the sex of type 1 diabetic parent and the variable in question was not statistically significant.

  • Interaction term between the sex of type 1 diabetic parent and the variable in question was statistically significant.