TABLE 2

OAS1 A/G splice-acceptor site SNP (rs10774671) allele and genotype frequencies and association test results in the type 1 diabetes family and the case-control collection

Family collectionTransmittedUntransmitted*RR (95% CI)P
AlleleTDT
    G (TDT)8418431.00 (0.91–1.10)0.96
GenotypeConditional logistic regression
    AA829 (43.3)2,484 (43.3)1.00 (ref.)
    GA848 (44.4)2,554 (44.5)1.00 (0.88–1.13)0.95
    GG236 (12.3)701 (12.2)1.01 (0.82–1.24)0.92
    GG+GA1,084 (56.7)3,255 (56.7)1.00 (0.88–1.13)0.96
Case-control collectionCases (n = 4,287)Control subjects (n = 4,735)OR (95% CI)P
AlleleLogistic regression
    A5,522 (64.4)6,093 (64.3)1.00 (ref.)
    G3,052 (35.6)3,377 (35.7)0.99 (0.93–1.06)0.83
Genotype
    AA1,779 (41.5)1,945 (41.1)1.00 (ref.)
    GA1,964 (45.8)2,203 (46.5)0.96 (0.88–1.05)0.40
    GG544 (12.7)587 (12.4)1.01 (0.88–1.16)0.86
    GG+GA2,508 (58.5)2,790 (58.9)0.97 (0.89–1.06)0.52
  • Data are n (%) unless otherwise indicated. Families comprise U.K., U.S., Norway, and Romania.

  • *

    * Untransmitted (pseudo-control) data for genotypes in the type 1 diabetic family collection are estimated, as in Cordell and Clayton (13). OR, odds ratio.