TABLE 2

Clinical and biochemical characteristics of the nondiabetic group according to the IL-10 genotype

−1082G/A polymorphism
−592C/A polymorphism
A/AG/AG/GPC/CC/AA/APP (A/A vs. C/A + C/C)*
n (male/female)207/278217/29957/730.93282/333171/27828/390.040.9
Age (years)48 ± 1447 ± 1447 ± 130.2448 ± 1447 ± 1449 ± 130.520.41
BMI (kg/m2)29.9 ± 6.729.2 ± 6.329.3 ± 6.70.1529.3 ± 6.429.4 ± 6.631.6 ± 6.40.010.003
Waist-to-hip ratio0.90 ± 0.090.91 ± 0.100.90 ± 0.120.320.90 ± 0.100.89 ± 0.080.92 ± 0.09§0.0490.29
Systolic blood pressure (mmHg)124 ± 17121 ± 14118 ± 130.15121 ± 15123 ± 16129 ± 15**0.040.02
Diastolic blood pressure (mmHg)79 ± 1078 ± 1077 ± 90.7377 ± 1079 ± 982 ± 110.120.13
Fasting glucose (mg/dl)92 ± 1092 ± 1092 ± 110.6692 ± 1091 ± 1095 ± 100.0590.04
2-h postchallenge glucose (mg/dl) (n = 734)116 ± 32115 ± 33114 ± 290.79115 ± 32115 ± 33125 ± 260.150.053
Total cholesterol (mg/dl)205 ± 41203 ± 40197 ± 390.14202 ± 40205 ± 42205 ± 380.460.76
HDL cholesterol (mg/dl)52 ± 1452 ± 1353 ± 140.8551 ± 1353 ± 1449 ± 140.020.048
Triglycerides (mg/dl)128 ± 67124 ± 68114 ± 690.06122 ± 61127 ± 74136 ± 850.440.26
Fasting insulin (μU/ml)13 ± 1013 ± 1012 ± 80.8313 ± 1012 ± 817 ± 140.0010.001
HOMA-IR3.2 ± 2.63.1 ± 2.62.9 ± 1.80.793.1 ± 2.62.8 ± 2.14.3 ± 4.4#††0.00010.0001
HOMA of β-cell function199 ± 200194 ± 219181 ± 1500.83201 ± 234188 ± 168192 ± 1140.510.26
Plasma IL-10 (pg/ml) (n = 236)1.5 ± 1.51.9 ± 2.01.9 ± 1.50.302.1 ± 2.01.5 ± 1.21.1 ± 0.80.040.035
  • Data are means ± SD. P values for comparisons of differences of continuous variables between the three genotypes using ANOVA.

  • *

    * P values for comparisons of differences of continuous variables between two genotypes using unpaired Student’s t test. Categorical variables were compared by χ2 test.

  • P = 0.01 vs. C/C;

  • P = 0.01 vs. C/A;

  • §

    § P = 0.04 vs. C/A;

  • P = 0.005 vs. C/C;

  • P = 0.001 vs. C/A;

  • #

    # P< 0.0001 vs. C/A after Bonferroni correction for multiple comparisons;

  • **

    ** P = 0.04 vs. C/C;

  • ††

    †† P = 0.002 vs. C/C.