TABLE 1

Physiological and metabolic parameters in control and MB06322-treated pre-diabetic male ZDF rats (nonfasted)*

ParameterControl
MB06322 (0.4%) prevention
MB06322 (0.4%) intervention
Age 6 weeksAge 10 weeksAge 12 weeksAge 6 weeksAge 10 weeksAge 12 weeksAge 10 weeksAge 12 weeks
Length of treatment (weeks)04604602
Lactate (mmol/l)1.85 ± 0.111.9 ± 0.091.73 ± 0.051.76 ± 0.091.89 ± 0.212.66 ± 0.621.83 ± 0.153.11 ± 0.27
NEFA (mmol/l)0.9 ± 0.042.1 ± 0.14.9 ± 0.21.0 ± 0.052.8 ± 0.26.1 ± 0.221.8 ± 0.25.23 ± 3
Triglycerides (mg/dl)191 ± 11598 ± 45609 ± 53210 ± 17713 ± 571,016 ± 97640 ± 60945 ± 88
Cholesterol (mg/dl)72 ± 3137 ± 4144 ± 583 ± 3152.±8175 ± 20153 ± 6236 ± 8
β-OH-butyrate (μmol/l)223 ± 14158 ± 17182 ± 12
Water intake (ml/day)28 ± 3111 ± 5144 ± 430 ± 144 ± 535 ± 4116 ± 242 ± 2
Food intake (g/day)28 ± 133 ± 036 ± 027 ± 033 ± 136 ± 232 ± 033 ± 0
Body weight (g)184 ± 3337 ± 5365 ± 6191 ± 2361 ± 5423 ± 11335 ± 8358 ± 8
  • Data are means ± SE.

  • *

    * Weekly measurements were made. Parameters measured after 2 or 4 and 6 weeks of treatment are shown to highlight metabolic changes that occurred during these time periods.

  • The lactate elevations observed in the prevention and intervention groups were resolved within 3 days after the cessation of drug treatment;

  • P < 0.05 vs. control, Student’s t test.