Physiological and metabolic parameters in control and MB06322-treated pre-diabetic male ZDF rats (nonfasted): metabolic cage measurements
| Parameter | Control | MB06322 (0.4%) prevention | MB06322 (0.4%) intervention | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 weeks of treatment | 2.5 weeks of treatment | 4.5 weeks of treatment | 0.5 weeks of treatment | 2.5 weeks of treatment | 4.5 weeks of treatment | 0 weeks of treatment | 0.5 weeks of treatment | ||||||
| Age (weeks) | 6.5 | 8.5 | 10.5 | 6.5 | 8.5 | 10.5 | 10 | 10.5 | |||||
| Water intake (ml/day) | 27 ± 2.3 | 79 ± 8 | 151 ± 5 | 24 ± 2 | 37 ± 3* | 44 ± 7* | — | 79 ± 4* | |||||
| Urine output (ml/day) | 15 ± 1 | 62 ± 7 | 121 ± 5 | 14 ± 1 | 21 ± 2* | 29 ± 1* | — | 55 ± 3* | |||||
| Glucose excretion (g/day) | 0.38 ± 0.18 | 7.87 ± 1.67 | 16.74 ± 1.97 | 0.026 ± 0.07 | 0.99 ± 0.21* | 3.28 ± 1.59* | — | 5.25 ± 0.67* | |||||
Data are means ± SE.
* P < 0.05 vs. control for corresponding timepoint, unpaired Student’s t test.