TABLE 2

Physiological and metabolic parameters in control and MB06322-treated pre-diabetic male ZDF rats (nonfasted): metabolic cage measurements

ParameterControl
MB06322 (0.4%) prevention
MB06322 (0.4%) intervention
0.5 weeks of treatment2.5 weeks of treatment4.5 weeks of treatment0.5 weeks of treatment2.5 weeks of treatment4.5 weeks of treatment0 weeks of treatment0.5 weeks of treatment
Age (weeks)6.58.510.56.58.510.51010.5
Water intake (ml/day)27 ± 2.379 ± 8151 ± 524 ± 237 ± 3*44 ± 7*79 ± 4*
Urine output (ml/day)15 ± 162 ± 7121 ± 514 ± 121 ± 2*29 ± 1*55 ± 3*
Glucose excretion (g/day)0.38 ± 0.187.87 ± 1.6716.74 ± 1.970.026 ± 0.070.99 ± 0.21*3.28 ± 1.59*5.25 ± 0.67*
  • Data are means ± SE.

  • *

    * P < 0.05 vs. control for corresponding timepoint, unpaired Student’s t test.