TABLE 3

Physiological and metabolic parameters in control and MB06322-treated high-fat diet–fed female ZDF rats (nonfasted)

ParameterControl
MB06322 (100 mg · kg−1 · day−1)
MB06322 (300 mg · kg−1 · day−1)
0 days of treatment14 days of treatment0 days of treatment14 days of treatment0 days of treatment14 days of treatment
Insulin (ng/ml)29.3 ± 4.717.2 ± 3.428.6 ± 514.2 ± 126.9 ± 5.312.9 ± 1.4
Glucagon (pg/ml)122 ± 6114 ± 6108 ± 8
Lactate (mmol/l)1.22 ± 0.181.94 ± 0.461.12 ± 0.081.63 ± 0.511.58 ± 0.161.55 ± 0.26
NEFA (mmol/l)1.2 ± 0.31.1 ± 0.11.2 ± 0.1
Triglycerides (mg/dl)1,291 ± 1201,706 ± 2291,110 ± 1031,145 ± 1641,094 ± 1541,154 ± 60
Cholesterol (mg/dl)133 ± 8120 ± 5158 ± 4
β-Hydroxybutyrate (μmol/l)133 ± 13132 ± 16117 ± 12
Liver triglycerides (mg/g)15.3 ± 2.513 ± 312 ± 1
Liver glycogen (μmol/g)276 ± 11244 ± 13222 ± 13*
Alkaline phosphatase (IU/ml)196 ± 28110 ± 8*118 ± 14*
Water intake (ml/day)27 ± 531 ± 629 ± 515 ± 230 ± 616 ± 1
Food intake (g/day)16 ± 117 ± 115 ± 115 ± 115 ± 113 ± 2
Body weight (g)339 ± 5388 ± 7326 ± 4370 ± 4323 ± 7360 ± 9
  • Data are means ± SE.

  • *

    * P < 0.05 vs. control, ANOVA with Dunnett’s post hoc test.