TABLE 2

Steady-state characteristics: study 1. Results of hyperinsulinemic-euglycemic clamp experiment in dogs investigated after 3 weeks on a control diet (week 0) and after 12 weeks on a hypercaloric high-fat diet (week 12)

Glucose (mg/dl)Insulin (pmol)Glucose infusion rate (mg · min−1 · kg−1)Glucose uptake (mg · min−1 · kg−1)Glucose production (mg · min−1 · kg−1)SiCLAMP*
Week 0100.2 ± 1.2413 ± 3511.8 ± 1.312.3 ± 1.30.12 ± 0.262.8 ± 0.4
Week 12100.0 ± 0.6482 ± 627.1 ± 0.67.9 ± 0.50.93 ± 0.131.6 ± 0.3
PNSNSP < 0.05P < 0.05P < 0.05P < 0.05
  • Data are means ± SE.

  • *

    * Insulin sensitivity [(dl · min−1 · kg−1 · pmol−1) × 105]; glucose uptake and production and insulin sensitivity determined from [3-3H]glucose tracer analysis.