TABLE 3

Model parameters: study 1. Effects of a high-fat diet on distribution kinetics of [14C]inulin: results from a hyperinsulinemic-euglycemic clamp experiment as performed before (week 0) and after (week 12) a hypercaloric high-fat diet in dogs

V1 (l)*V2 (l)*V3 (l)*CL01 (ml/min)CL2 (ml/min)CL3(ml/min)
Week 01.9 ± 0.25.2 ± 0.71.6 ± 0.3104 ± 1374 ± 5270 ± 54
Week 121.8 ± 0.33.7 ± 0.41.2 ± 0.1109 ± 1082 ± 6319 ± 73
PNSP < 0.05NSNSNSNS
  • Data are means ± SE.

  • *

    * Distribution volumes are indicated in liters instead of milliliters per kilogram body weight to account for the weight change during the diet (see Table 1). CL01, CL2, and CL3 indicate clearance and tissue-specific transport.