TABLE 4

Steady-state characteristics from study 2: results of hyperinsulinemic-euglycemic clamp experiment in anesthetized dogs

Glucose (mg/dl)Insulin (pmol)Glucose infusion rate (mg · min−1 · kg−1)Glucose uptake (mg · min−1 · kg−1)Glucose production (mg · min−1 · kg−1)
Clamp period infusion rates (mU · min−1 · kg−1)0.21.20.21.20.21.20.21.20.21.2
Control99.5 ± 1.7103.1 ± 1.9106 ± 10761 ± 832.3 ± 0.57.4 ± 0.33.2 ± 0.57.5 ± 0.30.82 ± 0.140.02 ± 0.04
Fat fed103.8 ± 2.6104.2 ± 2.3109 ± 8782 ± 930.3 ± 0.15.8 ± 0.61.8 ± 0.26.0 ± 0.71.34 ± 0.120.15 ± 0.12
PNSNSNSNSP < 0.01P < 0.05P < 0.05P < 0.05P < 0.05NS
  • Data are means ± SE. Two groups of dogs were compared: the control group after 3 weeks on a control diet (control) and the fat-fed group after 12 weeks on a hypercaloric high-fat diet (fat fed). The results of two steady-state clamp periods with different insulin infusion rates are indicated (0.2 and 1.2 mU · min−1 · kg−1). Glucose infusion rate, uptake, and production determined from [3-3H]glucose tracer analysis.