TABLE 5

Model parameters for study 2: results of hyperinsulinemic-euglycemic clamp experiments in anesthetized dogs

V1 (ml/kg)V2 (ml/kg)V3 (ml/kg)CL01 (ml/min)CL2 (ml/min)CL3(ml/min)
Low insulin46 ± 7 (46 ± 7)93 ± 9 (98 ± 6)22 ± 3 (21 ± 5)95 ± 7 (91 ± 9)84 ± 13 (78 ± 8)200 ± 39 (211 ± 66)
High insulin43 ± 6 (44 ± 5)111 ± 14 (139 ± 16)24 ± 3 (27 ± 6)87 ± 7 (87 ± 10)75 ± 11 (80 ± 10)207 ± 26 (219 ± 61)
Δ (%)7 (−1)18 (32)6 (18)8 (−1)11 (13)11 (19)
PNS (NS)NS (P < 0.01)NS (NS)NS (NS)NS (NS)NS (NS)
  • Data are means ± SE. Compartment model analysis for two different insulin clamp levels are indicated (low insulin 0.2 mU · min−1 · kg−1 and high insulin 1.2 mU · min−1 · kg−1). Results from dogs after 12 weeks on a high-fat diet are indicated in bold; results after 3 weeks on a control diet are in parentheses. CL01, CL2, and CL3 indicate clearance and tissue-specific transport.