TABLE 1

Characterization of the HFD/STZ mouse model

Blood glucose (mg/dl)Plasma insulin (ng/ml)Plasma triglyceride (mg/dl)Plasma FFA (mmol/l)Body weight (g)
Control141 ± 60.90 ± 0.09158 ± 182.3 ± 0.239.3 ± 1.1
STZ alone191 ± 290.58 ± 0.09*143 ± 132.3 ± 0.236.8 ± 1.0*
HFD alone169 ± 201.14 ± 0.17146 ± 182.1 ± 0.146.7 ± 2.2*
HFD/STZ310 ± 16*0.56 ± 0.05*447 ± 115*4.2 ± 0.5*40.6 ± 1.1
  • Data are means ± SE (n = 8–10). ICR mice were fed with regular diet and injected with saline (control) or STZ (STZ alone) or fed with HFD and injected with saline (HFD alone) or STZ (HFD/STZ). Blood glucose, plasma insulin, triglycerides, FFAs, and body weight were measured under the fed condition.

  • *

    * P < 0.05 comparing control and treated group.