TABLE 2

Ranking of differentially expressed pathways in visceral fat between nonobese and type 2 diabetic women

TypeLevelChanged (n)Measured (n)OnMAPP (n)Changed (%)z scoreAdjusted P
Downregulated in type 2 diabetes
    GenMAPP
        Hs_Ribosomal_Proteins328788378.4<0.001
        Hs_Electron_Transport_Chain2891105316.7<0.001
        Hs_Translation_Factors195050386.6<0.001
        Hs_Krebs-TCA_Cycle123131395.3<0.001
    Gene ontology
        RibosomeC4331291672610.4<0.001
        Structural constituent of ribosomeF246177232269.9<0.001
        MitochondrionC479416464199.9<0.001
        Cytosolic large ribosomal subunitC2183839479.70.001
        Ribonucleoprotein complexC352836189.70.001
        Hydrogen ion transporter activityF592733339.20.001
        Protein biosynthesisP451197252269.10.001
        RNA bindingF370378472199.10.001
        CytoplasmC366557636128.50.002
        CytosolC414135141107.90.005
Upregulated in type 2 diabetes
    GenMAPP
        Hs_mRNA_processing_Reactome16125129134.30.048
  • Ranking was performed in MAPPFinder, using the criteria from SAM (Table 1). Genes that were up- or downregulated in type 2 diabetes were analyzed separately. For genes downregulated in type 2 diabetes, the local map z score is based on n = 2,302 distinct genes linked to local maps and R = 232 of these genes meeting the SAM criteria for change in expression. For gene ontology, the z score is based on n = 11,488 distinct genes linked to a gene ontology term and R = 811 of these genes meeting the criteria for change in expression. For genes upregulated in type 2 diabetes, the local map z score is based on n = 2,302 distinct genes linked to local maps and R = 110. In the analysis of upregulated genes, no gene ontology term displayed adjusted P value <0.05. Shown are maps and terms with adjusted P value <0.05. Level refers to steps below major gene ontology terms. C, cellular component; F, molecular function; P, biological process.