Ranking of differentially expressed pathways in visceral fat between nonobese and type 2 diabetic women
| Type | Level | Changed (n) | Measured (n) | OnMAPP (n) | Changed (%) | z score | Adjusted P | |
|---|---|---|---|---|---|---|---|---|
| Downregulated in type 2 diabetes | ||||||||
| GenMAPP | ||||||||
| Hs_Ribosomal_Proteins | — | — | 32 | 87 | 88 | 37 | 8.4 | <0.001 |
| Hs_Electron_Transport_Chain | — | — | 28 | 91 | 105 | 31 | 6.7 | <0.001 |
| Hs_Translation_Factors | — | — | 19 | 50 | 50 | 38 | 6.6 | <0.001 |
| Hs_Krebs-TCA_Cycle | — | — | 12 | 31 | 31 | 39 | 5.3 | <0.001 |
| Gene ontology | ||||||||
| Ribosome | C | 4 | 33 | 129 | 167 | 26 | 10.4 | <0.001 |
| Structural constituent of ribosome | F | 2 | 46 | 177 | 232 | 26 | 9.9 | <0.001 |
| Mitochondrion | C | 4 | 79 | 416 | 464 | 19 | 9.9 | <0.001 |
| Cytosolic large ribosomal subunit | C | 2 | 18 | 38 | 39 | 47 | 9.7 | 0.001 |
| Ribonucleoprotein complex | C | 3 | 5 | 28 | 36 | 18 | 9.7 | 0.001 |
| Hydrogen ion transporter activity | F | 5 | 9 | 27 | 33 | 33 | 9.2 | 0.001 |
| Protein biosynthesis | P | 4 | 51 | 197 | 252 | 26 | 9.1 | 0.001 |
| RNA binding | F | 3 | 70 | 378 | 472 | 19 | 9.1 | 0.001 |
| Cytoplasm | C | 3 | 66 | 557 | 636 | 12 | 8.5 | 0.002 |
| Cytosol | C | 4 | 14 | 135 | 141 | 10 | 7.9 | 0.005 |
| Upregulated in type 2 diabetes | ||||||||
| GenMAPP | ||||||||
| Hs_mRNA_processing_Reactome | — | — | 16 | 125 | 129 | 13 | 4.3 | 0.048 |
Ranking was performed in MAPPFinder, using the criteria from SAM (Table 1). Genes that were up- or downregulated in type 2 diabetes were analyzed separately. For genes downregulated in type 2 diabetes, the local map z score is based on n = 2,302 distinct genes linked to local maps and R = 232 of these genes meeting the SAM criteria for change in expression. For gene ontology, the z score is based on n = 11,488 distinct genes linked to a gene ontology term and R = 811 of these genes meeting the criteria for change in expression. For genes upregulated in type 2 diabetes, the local map z score is based on n = 2,302 distinct genes linked to local maps and R = 110. In the analysis of upregulated genes, no gene ontology term displayed adjusted P value <0.05. Shown are maps and terms with adjusted P value <0.05. Level refers to steps below major gene ontology terms. C, cellular component; F, molecular function; P, biological process.