Downregulated expression of electron transport chain genes in visceral fat of type 2 diabetic women
| Genes in complex (number measured)* | Visceral fat | Subcutaneous fat | ||
|---|---|---|---|---|
| Type 2 diabetic/control | Obese/control | Type 2 diabetic/control | ||
| Complex I | ||||
| NADH-ubiquinone oxidoreductase (35) | ||||
| NDUFA3 | 0.73 | 1.08 | 0.97 | |
| NDUFA6 | 0.78 | 0.97 | 0.95 | |
| NDUFC2 | 0.69 | 0.94 | 0.96 | |
| NDUFB4 | 0.78 | 0.95 | 0.84 | |
| DAP13 | 0.63 | 0.84 | 0.74† | |
| NDUFB9 | 0.71 | 0.89 | 0.91 | |
| NDUFA1 | 0.83 | 0.98 | 0.92 | |
| NDUFB5 | 0.76 | 0.84 | 0.77 | |
| NDUFV2 | 0.71 | 0.83 | 0.80 | |
| NDUFS3 | 0.70 | 0.82 | 0.89 | |
| NDUFS1 | 0.77 | 0.91 | 0.72† | |
| Complex II | ||||
| Succinate-ubiquinone oxidoreductase (4) | ||||
| SDHD | 0.76 | 0.94 | 0.76† | |
| Complex III | ||||
| Ubiquinol-cytochrome C reductase (8) | ||||
| UQCRH | 0.75 | 0.84 | 0.84 | |
| Complex IV | ||||
| Cytochrome C oxidase (12) | ||||
| COX4L1 | 0.76 | 0.83 | 0.90 | |
| COX5A | 0.71 | 0.81 | 1.00 | |
| COX5B | 0.67 | 0.93 | 0.82 | |
| COX6A1 | 0.85 | 0.89 | 1.02 | |
| COX6B1 | 0.76 | 1.08 | 1.03 | |
| COX6C | 0.85 | 1.00 | 0.97 | |
| COX7B | 0.75 | 0.99 | 0.88 | |
| Assembly (5)‡ | ||||
| Complex V | ||||
| F1 Complex (5) | ||||
| ATP5A1 | 0.80 | 1.00 | 0.85 | |
| ATP5C1 | 0.75 | 0.85 | 0.89 | |
| ATP5E | 0.75 | 0.83 | 1.06 | |
| Stalk (2,2) | ||||
| ATP5O | 0.80 | 0.88 | 0.89 | |
| F0 complex (9) | ||||
| ATP5F1 | 0.68 | 0.89 | 0.87 | |
| ATP5G3 | 0.77 | 0.86 | 1.02 | |
| ATP5L | 0.69 | 0.87 | 0.81 | |
| Uncoupling protein (5) | ||||
| UCP2 | 0.55 | 0.73 | 1.01 | |
| Adenine nucleotide translocator (3)‡ | ||||
* A total of 28 electron transport chain genes downregulated in visceral fat of type 2 diabetic women versus nonobese control subjects according to SAM;
† genes downregulated according to SAM in subcutaneous fat;
‡ expression of no gene in these complexes was dependent of type 2 diabetes status.