Downregulated expression of electron transport chain genes in visceral fat of type 2 diabetic women

Genes in complex (number measured)*Visceral fat
Subcutaneous fat
Type 2 diabetic/controlObese/controlType 2 diabetic/control
Complex I
    NADH-ubiquinone oxidoreductase (35)
Complex II
    Succinate-ubiquinone oxidoreductase (4)
Complex III
    Ubiquinol-cytochrome C reductase (8)
Complex IV
    Cytochrome C oxidase (12)
    Assembly (5)
Complex V
    F1 Complex (5)
    Stalk (2,2)
    F0 complex (9)
    Uncoupling protein (5)
    Adenine nucleotide translocator (3)
  • *

    * A total of 28 electron transport chain genes downregulated in visceral fat of type 2 diabetic women versus nonobese control subjects according to SAM;

  • genes downregulated according to SAM in subcutaneous fat;

  • expression of no gene in these complexes was dependent of type 2 diabetes status.