TABLE 3

Downregulated expression of electron transport chain genes in visceral fat of type 2 diabetic women

Genes in complex (number measured)*Visceral fat
Subcutaneous fat
Type 2 diabetic/controlObese/controlType 2 diabetic/control
Complex I
    NADH-ubiquinone oxidoreductase (35)
        NDUFA30.731.080.97
        NDUFA60.780.970.95
        NDUFC20.690.940.96
        NDUFB40.780.950.84
        DAP130.630.840.74
        NDUFB90.710.890.91
        NDUFA10.830.980.92
        NDUFB50.760.840.77
        NDUFV20.710.830.80
        NDUFS30.700.820.89
        NDUFS10.770.910.72
Complex II
    Succinate-ubiquinone oxidoreductase (4)
        SDHD0.760.940.76
Complex III
    Ubiquinol-cytochrome C reductase (8)
        UQCRH0.750.840.84
Complex IV
    Cytochrome C oxidase (12)
        COX4L10.760.830.90
        COX5A0.710.811.00
        COX5B0.670.930.82
        COX6A10.850.891.02
        COX6B10.761.081.03
        COX6C0.851.000.97
        COX7B0.750.990.88
    Assembly (5)
Complex V
    F1 Complex (5)
        ATP5A10.801.000.85
        ATP5C10.750.850.89
        ATP5E0.750.831.06
    Stalk (2,2)
        ATP5O0.800.880.89
    F0 complex (9)
        ATP5F10.680.890.87
        ATP5G30.770.861.02
        ATP5L0.690.870.81
    Uncoupling protein (5)
        UCP20.550.731.01
    Adenine nucleotide translocator (3)
  • *

    * A total of 28 electron transport chain genes downregulated in visceral fat of type 2 diabetic women versus nonobese control subjects according to SAM;

  • genes downregulated according to SAM in subcutaneous fat;

  • expression of no gene in these complexes was dependent of type 2 diabetes status.