TABLE 3

Tests of multipoint linkage and association of GAD2 with BMI

Associated GAD2 SNP(s)Analyses assuming one SNP cluster
Analyses assuming three SNP clusters
Linkage alone (LOD)Linkage given association (LOD)Linkage alone (LOD)Linkage given association (LOD)
rs28396693.883.544.323.94
rs22364184.083.584.624.09
rs2839669, rs22364184.193.794.774.31
rs70719222.882.793.253.12
rs7071922, rs3781117, rs79089752.802.553.183.00
rs9281973.633.144.193.63
rs992990, rs928197, rs37811073.282.883.843.47
  • Linkage alone: baseline multipoint LOD score for linkage to BMI calculated only in those individuals who have genotypes for the GAD2 SNP in question. Linkage given association: multipoint LOD score for linkage to BMI after the GAD2 association has been accounted for, by adjustment on the GAD2 covariate.