TABLE 1

Clinical characteristics of study subjects

Study (n)Ascertainment criteriaAutoantibody positivity*Range of age at onset (years)Age at onset (years)Duration of diabetes (years)BMI (kg/m2)Male sex (%)Insulin requiring by 3 years postdiagnosis (%)
UKPDS (232)Newly diagnosed type 2 diabetes: not insulin requiring within 3 months of diagnosis, ketonuria <3 mmol/lGADA and/or IA-2A25–6546.7 ± 10.6Studied at diagnosis25.2 ± 4.95351
W2 Repository (131)Clinical diagnosis of type 2 diabetes: not insulin requiring within 12 months of diagnosisGADA26–6847.4 ± 10.08.9 ± 6.728.6 ± 5.35741
Exeter YT2D (37)Clinical diagnosis of type 2 diabetes: not insulin requiring within 3 months of diagnosisGADA and/or IA-2A29–4538.4 ± 5.411.9 ± 7.727.5 ± 5.84357
Control subjects (332)Spouses/friends of probands collected in the DIF study, normoglycemicNegative for GADA and IA-2A20–9155.5 ± 19.8N/A25.4 ± 4.045N/A
  • Data are means ± SD unless otherwise indicated.

  • *

    * Antibody measurements were made in the accredited laboratory of Professor Bingley (University of Bristol) for the UKPDS, Exeter YT2D, and Diabetes in Families (DIF) cohorts and in the laboratory of Professor Bottazzo (Royal London Hospital) for the W2 Repository.

  • At diagnosis;

  • at time of sample collection.