TABLE 3

Single-point association analysis of the −23HphI, +1404Fnu4HI, and +3580MspI SNPs with disease in the LADA groups assuming dominance for the protective allele

Sample group (n)*−23HphI
+1404Fnu4HI
+3580MspI
OR (95% CI)POR (95% CI)POR (95% CI)P
UKPDS LADA (232)0.38 (0.26–0.55)9.3 × 10−80.41 (0.27–0.62)6.8 × 10−60.45 (0.28–0.73)7.2 × 10−4
W2 Repository LADA (131)0.58 (0.38–0.90)0.0130.73 (0.46–1.15)0.160.74 (0.40–1.40)0.35
Exeter YT2D LADA (37)0.22 (0.08–0.53)0.000190.37 (0.13–0.90)0.0190.86 (0.31–3.00)0.79
All cases (400)0.42 (0.31–0.58)2.4 × 10−80.50 (0.36–0.70)3.2 × 10−50.55 (0.35–0.85)0.0046
  • ORs (95% CIs) were calculated based on the dominant model of inheritance for the allele at each SNP known to be associated with protection from type 1 diabetes: 23HphI, dominant for T allele (VNTR class III alleles); +1404Fnu4HI, dominant for A allele; +3580MspI, dominant for C allele. All comparisons were carried out between the case group concerned and the common control set.

  • *

    * Individuals in whom genotyping was attempted.