TABLE 1

The frequency of HLA class II genotypes in 32 individuals with a defined mutation in KCNJ11 and in 155 negative for mutations in KCNJ11 46 diagnosed before and 109 after the age of 6 months

KCNJ11 Mut +veKCNJ11 Mut–ve (0–6 months)Kir6.2 Mut–ve (>6 months)Healthy control subjects
n3247108621
Genotype
DR4-DQ8/DR3-DQ21 (3%)4 (9%)54 (50%)17 (3%)
DR4-DQ8/X6 (19%)7 (15%)18 (16%)85 (14%)
DR3-DQ2/X7 (22%)7 (15%)30 (28%)167 (26%)
X/X13 (40%)21 (44%)2 (2%)249 (40%)
DR2-DQ6/ DR2-DQ6 or DR2-DQ6/X5 (16%)8 (17%)4 (4%)103 (17%)
  • Control data are provided for 621 healthy Caucasians. The genotypes HLA DRB1*04-DQB1*0302/ HLA DRB1*03-DQB1*0201, HLA DRB1*04-DQB1*0302/X, and HLA DRB1*03-DQB1*0201/X are described as DR4-DQ8/DR3-DQ2, DR4-DQ8/X, and DR3-DQ2/X, respectively, where X is not DRB1*02-DQB1*0602 (DR2-DQ6). +ve, mutation present; −ve, mutation not detected by sequencing.