TABLE 3

HRs derived from a stepwise proportional hazards regression models for albuminuria outcomes and renal insufficiency outcomes (n = 2,167)

VariableAlbuminuria
Renal insufficiency
Microalbuminuria (N events = 756)
Macroalbuminuria (N events = 219)
Creatinine clearance ≤60 ml/min per 1.73 m2 (N events = 584)
Doubling of plasma creatinine (N events = 58)
Order enteredHR (95% CI)POrder enteredHR (95% CI)POrder enteredHR (95% CI)POrder enteredHR (95% CI)P
Age at diagnosis (per 5 years)1.01 (0.97–1.06)0.581.02 (0.94–1.12)0.592.15 (1.98–2.34)<0.00010.91 (0.77–1.07)0.25
Sex (male)1.18 (1.01–1.39)0.0411.47 (1.06–2.02)0.0200.550 (0.424–0.715)<0.00010.87 (0.51–1.48)0.61
Ethnicity
    White Caucasian1111
    Afro-Caribbean1.21 (0.89–1.65)0.221.05 (0.59–1.86)0.871.26 (0.91–1.76)0.170.40 (0.10–1.68)0.21
    Indian Asian2.02 (1.59–2.60)<0.00012.07 (1.36–3.15)0.000661.93 (1.38–2.72)0.000151.51 (0.59–3.90)0.39
Urinary albumin (per 20 mg/l)31.004 (1.002–1.007)0.0006611.009 (1.005–1.012)<0.000151.009 (1.002–1.015)0.0075
Plasma creatinine (per 10 μmol/l)81.087 (1.005–1.175)0.03821.34 (1.28–1.40)<0.0001
Smoking status (ever)91.20 (1.01–1.42)0.03671.25 (1.03–1.52)0.022
Waist (cm)71.010 (1.004–1.016)0.0004241.016 (1.006–1.026)0.001910.95 (0.94–0.96)<0.0001
Height (cm)31.05 (1.036–1.072)<0.0001
Systolic blood pressure (per 10 mmHg)11.15 (1.11–1.20)<0.000131.15 (1.07–1.24)0.0001941.107 (1.06–1.16)0.00001211.39 (1.23–1.57)<0.0001
A1C (%)61.08 (1.03–1.12)0.0003161.10 (1.02–1.18)0.011
LDL cholesterol (mmol/l)71.17 (1.02–1.33)0.022
HDL cholesterol (mmol/l)32.78 (1.01–7.68)0.049
Plasma triglycerides (mmol/l)*21.09 (1.04–1.14)<0.000121.15 (1.09–1.21)<0.0001
White cell count (109/l)51.06 (1.02–1.10)0.0012
Previous retinopathy81.25 (1.05–1.49)0.01271.255 (1.020–1.544)0.032
Previous sensory neuropathy21.84 (1.03–3.30)0.039
Previous CVD41.46 (1.23–1.73)<0.000151.58 (1.16–2.15)0.0041
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    * Log10 transformed.