TABLE 1

Final blood glucose values and starting and ending body weights for all groups

Experimental groupNumber of ratsBlood glucose (mmol/l)Body weight (g)
StartEnd
Dose-ranging study
    Controls (nondiabetic; not injected)105.2 ± 0.9306 ± 19547 ± 60
    Diabetic pVAX-11227.9 ± 3.5297 ± 11390 ± 22
    Diabetic VZ+434 (31.25 μg)1128.9 ± 4.0304 ± 10385 ± 58
    Diabetic VZ+434 (62.5 μg)1328.3 ± 3.9300 ± 13368 ± 45
    Diabetic VZ+434 (125 μg)1029.0 ± 3.0302 ± 15372 ± 52
    Diabetic VZ+434 (250 μg)1429.0 ± 2.7295 ± 10366 ± 37
Repeat-dosing study
    Control (untreated)127.0 ± 1.0285 ± 13534 ± 39
    Diabetic pVAX-1 (repeat injections)1325.8 ± 2.6288 ± 15349 ± 72
    Diabetic VZ+434 (repeat injections)1128.7 ± 3.9292 ± 10354 ± 40
  • Data are means ± SD from triplicate measurements for blood glucose.